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Description
NTB-A/SLAMF6 His Tag Protein, HumanProduct Specification Species Human Synonyms NTB A, SLAMF6, Ly108, NK T B antigen, CD352, KALI Accession Q96DU3 1 Amino Acid Sequence Gln22 Met226, with C terminal His Expression System HEK293 Molecular Weight 33 43kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer 1*PBS, pH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | NTB-A, SLAMF6, Ly108, NK-T-B-antigen, CD352, KALI |
| Accession | Q96DU3-1 |
| Amino Acid Sequence | Gln22-Met226, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 33-43kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 1*PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Rietdijk, Keszei, Castro, Terhorst, Abadía-Molina (2023) Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice. Int J Mol Sci (IF: 5.6) 24(5). |
Background
SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6-related genes is located within a 400–500 kilobase (kb) genomic segment on chromosome 1 in humans and mice. The genes that encode the SLAM family were created by serial gene duplication. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
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